Biological Products Filtration Solutions

Biological products refer to drugs prepared from microbial, cellular, and various animal and human tissues and fluids obtained through biotechnology such as genetic engineering, cell engineering, protein engineering, and fermentation engineering, and are used for the prevention, treatment, and diagnosis of human diseases.Because biological products need to go through multiple biological processes and purification processes to remove impurities in order to obtain the desired products, biological products have extremely complex uncertainties at every step. The quality control of biological products throughout the entire process has strict requirements, so filtration is crucial for process control. Take vaccines as an example.

Injection needle extracting biologics from ampoule
Vaccine Production Filtration Process

Vaccines are preventive biologics used for human immunization to prevent and control the occurrence and spread of infectious diseases. The principle behind vaccines is to use artificially attenuated, inactivated, or genetically modified pathogenic microorganisms (such as bacteria, rickettsiae, viruses, etc.) and their metabolites to produce automatic immunizing agents for preventing infectious diseases. Currently, the majority of vaccines used are for preventing viral or bacterial infections, and they are mainly categorized as inactivated vaccines, live attenuated vaccines, toxoids, subunit vaccines, polysaccharide vaccines, nucleic acid vaccines (DNA vaccines and RNA vaccines), etc.

Vaccine production filtration process diagram
Filter Sites and Recommended Products
Workstation Function Recommended Filter Cartridge Series Recommended Filter Housing Series
1 Culture medium filtration Remove bacteria and microorganisms from cell culture medium.
  • PP pleated filter cartridge
  • PP capsule filter cartridge
  • PES pleated filter cartridge
  • Nylon pleated filter cartridge
  • Hydrophilic PVDF pleated filter cartridge
  • PES capsule filter cartridge
  • Liquid filter housing
2 Gas and respirator Removal of bacteria and other microorganisms in gases.
  • PTFE pleated filter cartridge
  • PTFE capsule filter cartridge
  • Respiratory filter housing
3 Clarification filtration Removal of dead cells, cell fragments, lipids, colloids, particles, and other impurities.
  • PP pleated filter cartridge
  • PP capsule filter cartridge
  • Liquid filter housing
4 Security filtration Pre-filtration before UF to protect the UF module.
  • PP pleated filter cartridge
  • Bag filter housing
  • Liquid filter housing
6 Buffer solution filtration Sterilization filtration of buffer solutions to extend the lifespan of chromatography columns and UF membranes.
  • PP pleated filter cartridge
  • PES pleated filter cartridge
  • PES capsule filter cartridge
  • Nylon pleated filter cartridge
  • Hydrophilic PVDF pleated filter cartridge
  • Liquid Filter Housing
7 Terminal sterilizing filter Remove bacteria and microorganisms from terminal filtrate.
  • PES pleated filter cartridge
  • Nylon pleated filter cartridge
  • Hydrophilic PVDF pleated filter cartridge
  • PES capsule filter cartridge
  • Inline pipeline filter housing
  • Liquid filter housing