Filtration Solutions for Sterile APIs

Raw materials refer to the raw materials used to produce various types of preparations. They are the active ingredients in the preparations, which are prepared by chemical synthesis, plant extraction, or biotechnology, and are used as medicinal powders, crystals, ointments, etc. that patients cannot take directly. According to the requirements of formulation production, the production of raw materials can be divided into aseptic raw material production and non-aseptic raw material production. Aseptic raw materials refer to raw materials that do not contain any active microorganisms, such as molds, bacteria, viruses, etc., and are upstream products of drug formulations. Take antibiotics as an example.

Various types of antibiotic capsules
Antibiotic Process Flowchart

Antibiotics refer to a class of secondary metabolites produced by microorganisms (including bacteria, fungi, and actinomycetes) or higher animals and plants during their life processes. They have the ability to interfere with the development function of other living cells and exhibit antimicrobial or other activities. Clinically used antibiotics include extracts from microbial cultures and compounds synthesized or semi-synthesized by chemical methods. Antibiotic raw materials, such as penicillin and cephalosporin, are usually obtained through semi-synthetic methods using fermentation and chemical synthesis.

Antibiotic process flow chart
Filter Sites and Recommended Products
Workstation Function Recommended Filter Cartridge Series Recommended Filter Housing Series
1 Security filtration Pre-filtration before UF to protect the UF module.
  • PP pleated filter cartridge
  • Bag filter housing
  • Liquid filter housing
2 Metal filter (titanium rod) Remove activated carbon particles to protect downstream filters. --
  • Titanium rod filter housing
3 Pre-filtration Reduce microbial load and extend the service life of downstream sterilizing filter cartridges.
  • PES pleated filter cartridge
  • Nylon pleated filter cartridge
  • PVDF pleated filter cartridge
  • PES capsule filter cartridge
  • Inline pipeline filter housing
  • Liquid filter housing
4 Sterilizing filtration Remove bacteria and microorganisms from the filtrate.
  • PES pleated filter cartridge
  • Nylon pleated filter cartridge
  • Hydrophilic PVDF pleated filter cartridge
  • PES capsule filter cartridge
  • Inline pipeline filter housing
  • Liquid filter housing
5 Terminal filtration Remove bacteria and microorganisms from terminal filtrate.
  • PES capsule filter cartridge
  • Nylon capsule filter cartridge
  • Hydrophilic PVDF pleated filter cartridge
  • PES capsule filter cartridge
  • Inline pipeline filter housing
  • Liquid filter housing
6 Respirator Balance tank pressure and prevent contamination.
  • PTFE pleated filter cartridge
  • PTFE capsule filter cartridge
  • Respiratory Filter Housing
7 UF step Remove particles, suspended solids, colloidal organic matter, microorganisms, etc.
  • Hollow Fiber Membrane
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